Fri. Jun 18th, 2021

Day: May 15, 2021

An X-ray crystallography picture displaying an ASH1L inhibitor developed at U-M in complicated with the protein. Credit score: Grembecka/Cierpicki Labs

The protein made by the ASH1L gene performs a key position within the growth of acute leukemia, together with different ailments. The ASH1L protein, nonetheless, has been difficult to focus on therapeutically.

Now a group of researchers led by Jolanta Grembecka, Ph.D., and Tomasz Cierpicki, Ph.D., from the College of Michigan has developed first-in-class small molecules to inhibit ASH1L’s SET area—stopping essential molecular interactions within the growth and development of leukemia.

The group’s findings, which used fragment-based screening, adopted by

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